Israeli attacks in Gaza killed hundreds of people and took fire from Yemen's Houthis after US airstrikes on the group, shattering a relative calm with the Iran-backed groups as the standoff over Tehran's festers.
Israel launched air strikes on the battered coastal enclave on Monday killing over 400 people according to the Hamas-run health ministry, appearing to end a two-month ceasefire brokered by the United States.
The strikes on some 80 targets aimed at Hamas mid-level and senior personnel and were over in about 10 minutes, an Israeli security official said according to an official press release.
Israeli Prime Minister Benjamin Netanyahu accused Hamas of intransigence as talks for it to release 59 hostages seized in the Oct. 7, 2023 attack on Israel - many of them dead - floundered.
Iran's foreign ministry spokesman Esmaeil Baghaei blamed the United States for the attack, saying it had direct responsibility for "the continuation of genocide in the occupied Palestinian territories".
Hours later, the Israeli military said it intercepted a ballistic missile fired from Yemen, shooting it down beyond Israel's borders.
Meanwhile, the US Central Command announced it had carried out fresh air raids on the armed Houthi movement in Yemen allied to Tehran, publishing videos on X showing fighter jets taking off from an aircraft carrier.
The ceasefire in Gaza had tamped down 15 months of conflict pitting Iran and its proxies against Israel throughout the region which saw Iran's so-called "Axis of Resistance" much degraded, with Hamas and Lebanese Hezbollah heavily hit.
Looming behind the uptick of violence, Iran has so far defied a demand by US President Donald Trump to come to a new deal over its disputed nuclear program or face a military intervention.
According to an official White House readout of a phone call between Trump and Russian President Vladimir Putin on Tuesday, "the two leaders shared the view that Iran should never be in a position to destroy Israel."
"The leaders spoke broadly about the Middle East as a region of potential cooperation to prevent future conflicts," the White House added. "They further discussed the need to stop proliferation of strategic weapons and will engage with others to ensure the broadest possible application."
The remarks suggest a fresh US bid to end the war in Ukraine may see Russia attempt to head off a conflict between its Iranian ally and the United States.
Tehran denies seeking nuclear weapons and top Iranian officials have vowed a devastating response to any attack.
US airstrikes hit dozens of Houthi targets throughout Yemen on Saturday in a bid to halt the Shi'ite armed groups attacks on commercial shipping and its own naval vessels, which have ensnared US sailors in the most intense fighting since World War II.
Yemen's Houthi foreign minister said the group will not halt its Red Sea attacks on shipping in solidarity with the Palestinians, saying Iran did not dictate its actions.
Trump on Monday warned the United States would punish Iran for any further attacks by the Houthis, which would be treated as emanating from the Islamic Republic itself.
Iran's military said its manned fighter aircraft had chased away an armed American attack drone in the skies off the Iranian coast, state media reported on Tuesday. There was no immediate reaction by the US armed forces.
The Pentagon on Monday indicated it did not seek an open-ended campaign in Yemen nor did it seek regime change, in an apparent reference to Iran.
“We will use overwhelming lethal force until we achieve our objective. And this is a very important point, this is not an endless offensive," spokesman Sean Parnell said.
"This is not about regime change in the Middle East, this is about protecting American interests.”
